Natty Gann (played by Meredith Salenger) is a twelve year old Depression era girl whose single-parent father leaves her behind in Chicago while he goes to Washington State to look for work in the timber industry. Natty runs away from the guardian she was left with to follow Dad. She befriends and is befriended by a wolf that has been abused in dog fights, hops a freight train west, and is presumed dead when her wallet is found after the train crashes. Dad gets bitter and endangers himself in his new job. Meanwhile Natty has a series of adventures and mis- adventures in various farmhouses, police stations, hobo camps, reform schools, and boxcars.

Gray and Sam are brother and sister and best friends, flatmates in New York City, where she creates ad campaigns and he's a surgery intern. Their social life is too insular, so they head to a dog park so Sam can, maybe, meet a woman. He does - Charlie - a zoologist new in the city; he likes her immediately, and the feeling seems mutual. As the three of them spend time together, what if Gray's feelings for Charlie aren't just sisterly? Not only might this explain her solitary life, but it could lead to real dilemmas - with Charlie (who's sweet, but a bit opaque) and with Sam. No advice comes from Gray's therapist, but a co-worker and a cab driver give theirs. Can Gray sort things out?